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Prof S M Best

In this course, we will begin by considering the various categories of medical device and how their function influences the testing that is relevant to their application. We then move on to considering the biological tissues that we might wish to repair and replace, and some of the biological responses that materials might illicit when implanted.

We then focus on one particular medical application: joint replacement. First, we consider the requirements in terms of the natural system that we aim to replace and then discuss in detail the range of materials and designs that are currently available - and in particular, their limitations. Finally we consider some new materials and applications that are currently under development, which may be used to treat patients in the future.

This lecture course will cover:

  • The requirements in the design of medical materials
  • The structure and properties of: collagen, tendon, ligament and skin and bone
  • The biological response to material (and the response of materials to the environment in the human body)
  • Joint replacement: the structure of synovial joints, and the design of implants for hip and knee replacement, focusing on the materials used in stem components, the articulating surfaces and the options for the fixation of the implants in bone.
  • New materials that are currently under development including synthetic polymers and composites and collagen-and ceramic-based scaffolds.